Reverse Cholesterol Transport (RCTr) is the mechanism by which excess cholesterol from peripheral tissues is transported to the liver for hepatobiliary excretion, thereby inhibiting foam cell formation and the development of atherosclerosis. Exercise affects RCTr, by influencing high-density lipoprotein cholesterol (HDL) through remodeling and by promoting hepatobiliary sterol excretion. High-intensity interval training (HIIT; 18 min) may have more cardioprotective effects than moderate-intensity continuous training (MIT; 1 h) against atherosclerosis, along with saving time, as supported by the changes observed in the main factors involved in the reverse cholesterol transport (RCT) process.
Saleh Rahmati-Ahmadabad, Mohammad-Ali Azarbayjani, Parvin Farzanegi, Lida Moradi, High-intensity interval training has a greater effect on reverse cholesterol transport elements compared with moderate-intensity continuous training in obese male rats, European Journal of Preventive Cardiology, Volume 28, Issue 7, July 2021, Pages 692–701, https://doi.org/10.1177/2047487319887828.
